Afghanistan is a landlocked country, having high mountains and high percentage (46%) of permanent pastures. Many types of plants including different species of poisonous grow in the country. Many species of wild and domestic animals have free access to these poisonous plants. In developed countries, poisoning is counted as one of the most important problem for animals, but in Afghanistan it is remained among inconsiderable illness as compared to infectious or metabolic diseases. Yearly, several outbreaks of unknown diseases occur in those areas which are rich of poisonous plants and cause serious economic consequences and human health concerns. The effects of poisonous plants on animals in Afghanistan and its common clinical signs have been remained unrecognized. In this review, we investigate the most common poisonous plants to animals present in Afghanistan and its related clinical signs for early diagnosis of plant poisoning in domestic animals. This review will help readers to distinguish poisonous plants, toxic parts, poisoning signs and the areas where they grow.